Molecular epidemiology of Kaposi sarcoma virus in Spain.

ABSTRACT:

Background

Since human herpesvirus 8 (HHV-8) infection may be underestimated and HHV-8 subtype circulation in Spain remains unknown, a molecular epidemiologic study is highly desirable.

Objectives

This study aimed to analyse HHV-8 subtype diversity and their distribution in Spain.

Study design

The study included 142 HHV-8 infected patients. A nested PCR was developed in order to permit Sanger sequencing of HHV-8 K1 ORF directly from clinical samples received at the CNM from 2013 to 2021. Phylogenetic characterization was performed.

Results

Genotypes A and C comprised 55.6% and 42.3% of strains. Regarding subtypes, 25.4% of strains were C3, 19.7% were A3, 14.1% were A5, and C2, A1, A4, C1, A2, C7 were 11.3%, 11.3%, 8.5%, 4.2%, 2.1% and 1.4%, respectively. Subtyp

SUBMITTER: Gomez I 

PROVIDER: S-EPMC9595507 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature