Ontology highlight
ABSTRACT:
SUBMITTER: Haynes EM
PROVIDER: S-EPMC9596160 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Haynes Elizabeth M EM Burnett Korri H KH He Jiaye J Jean-Pierre Marcel W MW Jarzyna Martin M Eliceiri Kevin W KW Huisken Jan J Halloran Mary C MC
eLife 20221012
Development of elaborate and polarized neuronal morphology requires precisely regulated transport of cellular cargos by motor proteins such as kinesin-1. Kinesin-1 has numerous cellular cargos which must be delivered to unique neuronal compartments. The process by which this motor selectively transports and delivers cargo to regulate neuronal morphogenesis is poorly understood, although the cargo-binding kinesin light chain (KLC) subunits contribute to specificity. Our work implicates one such s ...[more]