Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation.

ABSTRACT: The differentiation of oligodendroglia from oligodendrocyte precursor cells (OPCs) to complex and extensive myelinating oligodendrocytes (OLs) is a multistep process that involves large-scale morphological changes with significant strain on the cytoskeleton. While key chromatin and transcriptional regulators of differentiation have been identified, their target genes responsible for the morphological changes occurring during OL myelination are still largely unknown. Here, we show that the regulator of focal adhesion, Tensin3 (Tns3), is a direct target gene of Olig2, Chd7, and Chd8, transcriptional regulators of OL differentiation. Tns3 is transiently upregulated and localized to cell processes of immature OLs, together with integrin-β1, a key mediator of survival at this transient stage. C

SUBMITTER: Merour E 

PROVIDER: S-EPMC9596163 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature