Association between work characteristics and epigenetic age acceleration: cross-sectional results from UK - Understanding Society study.

ABSTRACT: Occupation-related stress and work characteristics are possible determinants of social inequalities in epigenetic aging but have been little investigated. Here, we investigate the association of several work characteristics with epigenetic age acceleration (AA) biomarkers. The study population included employed and unemployed men and women (n = 631) from the UK Understanding Society study. We evaluated the association of employment and work characteristics related to job type, job stability; job schedule; autonomy and influence at work; occupational physical activity; and feelings regarding the job with four epigenetic age acceleration biomarkers (Hannum, Horvath, PhenoAge, GrimAge) and pace of aging (DunedinPoAm, DunedinPACE). We fitted linear regression models, unadjusted and adju

SUBMITTER: Freni-Sterrantino A 

PROVIDER: S-EPMC9596217 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature