Relationship between genome-wide and MHC class I and II genetic diversity and complementarity in a nonhuman primate.

ABSTRACT: Although mate choice is expected to favor partners with advantageous genetic properties, the relative importance of genome-wide characteristics, such as overall heterozygosity or kinship, versus specific loci, is unknown. To disentangle genome-wide and locus-specific targets of mate choice, we must first understand congruence in global and local variation within the same individual. This study compares genetic diversity, both absolute and relative to other individuals (i.e., complementarity), assessed across the genome to that found at the major histocompatibility complex (MHC), a hyper-variable gene family integral to immune system function and implicated in mate choice across species. Using DNA from 22 captive olive baboons (Papio anubis), we conducted double digest restriction si

SUBMITTER: Petersen RM 

PROVIDER: S-EPMC9596323 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature