Spatial heterogeneity in DNA methylation and chromosomal alterations in diffuse gliomas and meningiomas.

ABSTRACT: Adult-type diffuse gliomas and meningiomas are the most common primary intracranial tumors of the central nervous system. DNA methylation profiling is a novel diagnostic technique increasingly used also in the clinic. Although molecular heterogeneity is well described in these tumors, DNA methylation heterogeneity is less studied. We therefore investigated the intratumor genetic and epigenetic heterogeneity in diffuse gliomas and meningiomas, with focus on potential clinical implications. We further investigated tumor purity as a source for heterogeneity in the tumors. We analyzed genome-wide DNA methylation profiles generated from 126 spatially separated tumor biopsies from 39 diffuse gliomas and meningiomas. Moreover, we evaluated five methods for measurement of tumor purity and investig

SUBMITTER: Ferreyra Vega S 

PROVIDER: S-EPMC9596370 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature