Intratumoral PD-1⁺CD8⁺ T cells associate poor clinical outcomes and adjuvant chemotherapeutic benefit in gastric cancer.

ABSTRACT:

Background

Although PD-1 has been reported to be a marker of T-cell exhaustion in several malignancies, the biological role of PD-1⁺CD8⁺ T cells in gastric cancer (GC) remains unclear. Herein, we aimed to investigate the role of PD-1⁺CD8⁺ T cells in the tumour microenvironment and its clinical significance in GC.

Designs

This study included 441 tumour microarray specimens and 60 Flow cytometry specimens of GC patients from Zhongshan Hospital, and 250 GC patients from the Asian Cancer Research Group.

Results

Here, we demonstrated that PD-1⁺CD8⁺ T cells functioned as an independent adverse prognosticator in GC. In addition, an abundance of intratumoral PD-1⁺CD8⁺ T cells indicated wor

SUBMITTER: Yu K 

PROVIDER: S-EPMC9596411 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature