Spatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis.

ABSTRACT:

Background

Intraductal papillary neoplasms (IPN) and biliary epithelial neoplasia (BilIN) are well-defined precursor lesions of biliary tract carcinoma (BTC). The aim of this study was to provide a comprehensive characterisation of the inflammatory microenvironment in BTC precursor lesions.

Methods

Immunohistochemistry was employed to assess tumour-infiltrating immune cells in tissue samples from patients, for whom precursor lesions were identified alongside invasive BTC. The spatiotemporal evolution of the immune microenvironment during IPN-associated carcinogenesis was comprehensively analysed using triplet sample sets of non-neoplastic epithelium, precursor lesion and invasive BTC. Immune-cell dynamics during IPN- and BilIN-associated carcinogenesis were subsequently comp

SUBMITTER: Charbel A 

PROVIDER: S-EPMC9596479 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature