Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development.

ABSTRACT: Molecular clocks operate in peripheral tissues, including endocrine glands, and play important regulatory roles in this context. However, potential age-related changes in the expression rhythmicity of clock genes and the effects of these changes on the thyroid gland remain unknown. In the present study, we evaluated the expression rhythmicity of peripheral thyroid clock genes in aged mice using RNA-seq transcriptomic analysis in young (3.5-month) versus aged (20-month) mice. In addition, we determined the cellular effects of silencing of PER2, a major clock gene regulator, in human thyroid cell lines. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that differentially expressed genes (DEGs) in the thyroid glands of aged mice were involved in mitogen-acti

SUBMITTER: Lee J 

PROVIDER: S-EPMC9596494 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature