In human astrocytes neurotropic flaviviruses increase autophagy, yet their replication is autophagy-independent.

ABSTRACT: Astrocytes, an abundant type of glial cells, are the key cells providing homeostasis in the central nervous system. Due to their susceptibility to infection, combined with high resilience to virus-induced cell death, astrocytes are now considered one of the principal types of cells, responsible for virus retention and dissemination within the brain. Autophagy plays an important role in elimination of intracellular components and in maintaining cellular homeostasis and is also intertwined with the life cycle of viruses. The physiological significance of autophagy in astrocytes, in connection with the life cycle and transmission of viruses, remains poorly investigated. In the present study, we investigated flavivirus-induced modulation of autophagy in human astrocytes by monitoring a tandem

SUBMITTER: Tavcar Verdev P 

PROVIDER: S-EPMC9596533 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature