Oral intake of xanthohumol attenuates lipoteichoic acid-induced inflammatory response in human PBMCs.

ABSTRACT:

Purpose

The aim of the study was to determine if xanthohumol, a prenylated chalcone found in Hop (Humulus lupulus), has anti-inflammatory effects in healthy humans if applied in low doses achievable through dietary intake.

Methods

In a placebo-controlled single-blinded cross-over design study, 14 healthy young men and women either consumed a beverage containing 0.125 mg xanthohumol or a placebo. Peripheral blood mononuclear cells (PBMCs) were isolated before and 1 h after the intake of the beverages. Subsequently, PBMCs were stimulated with or without lipoteichoic acid (LTA) for 24 and 48 h. Concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6) and soluble cluster of differentiation (sCD14) protein were determined in cell culture supernatant. Furthermore, hTLR2 tran

SUBMITTER: Jung F 

PROVIDER: S-EPMC9596557 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature