Consumption of salmon fishmeal increases hepatic cholesterol content in obese C57BL/6 J mice.

ABSTRACT:

Purpose

By-products from farmed fish contain large amounts of proteins and may be used for human consumption. The purpose of this study was to investigate cardiometabolic effects and metabolic tolerance in mice consuming fishmeal from salmon by-products, salmon filet or beef.

Methods

Female C57BL/6J mice were fed chow, as a healthy reference group, or a high-fat diet for 10 weeks to induce obesity and glucose intolerance. Obese mice were subsequently given isocaloric diets containing 50% of the dietary protein from salmon fishmeal, salmon filet or beef for 10 weeks. Mice were subjected to metabolic phenotyping, which included measurements of body composition, energy metabolism in metabolic cages and glucose tolerance. Lipid content and markers of hepatic toxicity were determ

SUBMITTER: Hjorth M 

PROVIDER: S-EPMC9596588 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature