Evaluation of pharmacokinetics and safety of a long-term estradiol-releasing stent in rat uterine.

ABSTRACT:

Purpose

Intrauterine adhesion (IUA), often leading to gynecological complications including amenorrhea, abdominal pain and infertility, is frequently induced by injuries to the endometrium. Hence it would be of great benefit to take efforts to prevent adhesion after intrauterine operations. Orally administration of 17β-estradiol (E2) is commonly used to promote endometrium regeneration, but is limited by low concentrations at the injured sites. We aim at preparing an E2-releasing uterine stent, which could improve the efficiency of E2 therapy and be utilized for IUA prevention.

Methods

We designed a silicone rubber stent, which could be implanted in the uterine cavity and continuously release E2 in long term. Stents were placed in rodent uterine, and removed at different tim

SUBMITTER: Li B 

PROVIDER: S-EPMC9596602 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature