An in silico analysis of rpoB mutations to affect Chlamydia trachomatis sensitivity to rifamycin.

ABSTRACT:

Background

Chlamydia trachomatis is an obligate intracellular gram-negative pathogen, responsible for diverse affections, mainly trachoma and sexually transmitted diseases. Antibiotics are the commonly used drugs to tackle chlamydiae infections. However, when overused or wrongly used this may lead to strains' resistance to antibiotics, this phenomenon represents a real health problem worldwide. Numerous studies showed the association of Chlamydia trachomatis resistance with mutations in different genes; these mutations could have a deleterious or neutral impacts on the encoded proteins. The aim of this study is to perform an in silico analysis of C. trachomatis rpoB-encoded proteins using numerous bioinformatics tools and to identify the functional and structural-related effects of

SUBMITTER: Benamri I 

PROVIDER: S-EPMC9596629 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature