Excessive dietary linoleic acid promotes plasma accumulation of pronociceptive fatty acyl lipid mediators.

ABSTRACT: Various fatty acyl lipid mediators are derived from dietary polyunsaturated fatty acids (PUFAs) and modulate nociception. The modern diet is rich in linoleic acid, which is associated with nociceptive hypersensitivities and may present a risk factor for developing pain conditions. Although recommendations about fatty acid intake exist for some diseases (e.g. cardiovascular disease), the role of dietary fatty acids in promoting pain disorders is not completely understood. To determine how dietary linoleic acid content influences the accumulation of pro- and anti-nociceptive fatty acyl lipid mediators, we created novel rodent diets using custom triglyceride blends rich in either linoleic acid or oleic acid. We quantified the fatty acyl lipidome in plasma of male and female rats fed these cus

SUBMITTER: Birkic N 

PROVIDER: S-EPMC9596689 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature