Lcn2 mediates adipocyte-muscle-tumor communication and hypothermia in pancreatic cancer cachexia.

ABSTRACT:

Objective

Adipose tissue is the largest endocrine organ. When activated by cancer cells, adipocytes secrete adipocytokines and release fatty acids, which are then transferred to cancer cells and used for structural and biochemical support. How this metabolic symbiosis between cancer cells and adipocytes affects skeletal muscle and thermogenesis during cancer cachexia is unknown. Cancer cachexia is a multiorgan syndrome and how the communication between tissues is established has yet to be determined. We investigated adipose tissue secretory factors and explored their role in crosstalk of adipocytes, muscle, and tumor during pancreatic cancer cachexia.

Methods

We used a pancreatic cancer cachexia mouse model generated by syngenic implantation of pancreatic ductal adenocarcino

SUBMITTER: Lemecha M 

PROVIDER: S-EPMC9596731 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature