Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells.

ABSTRACT: Genomic imprinting is an epigenetic process through which genes are expressed in a parent-of-origin specific manner resulting in mono-allelic or strongly biased expression of one allele. For some genes, imprinted expression may be tissue-specific and reliant on CTCF-influenced enhancer-promoter interactions. The Peg13 imprinting cluster is associated with neurodevelopmental disorders and comprises canonical imprinted genes, which are conserved between mouse and human, as well as brain-specific imprinted genes in mouse. The latter consist of Trappc9, Chrac1 and Ago2, which have a maternal allelic expression bias of ∼75% in brain. Findings of such allelic expression biases on the tissue level raise the question of how they are reflected in individual cells and whe

SUBMITTER: Claxton M 

PROVIDER: S-EPMC9596773 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature