Titanium Sulfide Nanosheets Serve as Cascade Bioreactors for H₂ S-Mediated Programmed Gas-Sonodynamic Cancer Therapy.

ABSTRACT: Gas-mediated sonodynamic therapy (SDT) has the potential to become an effective strategy to improve the therapeutic outcome and survival rate of cancer patients. Herein, titanium sulfide nanosheets (TiS_X NSs) are prepared as cascade bioreactors for sequential gas-sonodynamic cancer therapy. TiS_X NSs themselves as hydrogen sulfide (H₂ S) donors can burst release H₂ S gas. Following H₂ S generation, TiS_X NSs are gradually degraded to become S-defective and partly oxidized into TiO_X on their surface, which endows TiS_X NSs with high sonodynamic properties under ultrasound (US) irradiation. In vitro and in vivo experiments show the excellent therapeutic effects of TiS_X NSs. In detail, large amount

SUBMITTER: Li G 

PROVIDER: S-EPMC9596849 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature