The current applications of cell-free fetal DNA in prenatal diagnosis of single-gene diseases: A review.

ABSTRACT: Prenatal diagnosis of hereditary diseases has substantially altered the way medical geneticists are helping families affected by genetic disorders. However, the risk of miscarriage and fear of invasive diagnostic procedures may discourage many couples from seeking prenatal diagnosis. With the discovery of maternal plasma cell-free fetal DNA, prenatal diagnosis has entered a new era of progress. Cell-free DNA is released during normal physiological functions as well as through the cell death programs of apoptosis and necrosis. It can be found in the plasma and other body fluids. Although this method has the advantage of being noninvasive, it is still rather expensive and requires advanced hardware and comprehensive data analysis. Promising implications of noninvasive prenatal diagnosis meth

SUBMITTER: Mahdi Mortazavipour M 

PROVIDER: S-EPMC9596931 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature