Distal neuropathic pain in HIV is associated with functional connectivity patterns in default mode and salience networks.

ABSTRACT: HIV-associated distal neuropathic pain (DNP) is one of the most prevalent, disabling, and treatment-resistant complications of HIV, but its biological underpinnings are incompletely understood. While data specific to mechanisms underlying HIV DNP are scarce, functional neuroimaging of chronic pain more broadly implicates the role of altered resting-state functional connectivity within and between salience network (SN) and default mode network (DMN) regions. However, it remains unclear the extent to which HIV DNP is associated with similar alterations in connectivity. The current study aimed to bridge this gap in the literature through examination of resting-state functional connectivity patterns within SN and DMN regions among people with HIV (PWH) with and without DNP. Resting state funct

SUBMITTER: Hays Weeks CC 

PROVIDER: S-EPMC9596968 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature