Factors influencing the SARS-CoV-2 infection and vaccination induced immune response in rheumatoid arthritis.

ABSTRACT:

Background

To investigate the factors that have significant impact on the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) infection and vaccination induced immune response in rheumatoid arthritis (RA).

Methods

Serological response was measured by quantifying anti-SARS-CoV-2 specific antibodies, while the cell-mediated response was measured by a whole-blood test quantifying the interferon (IFN)-γ response to different SARS-CoV-2-specific domains.

Results

We prospectively enrolled 109 RA patients and 43 healthy controls. The median time (IQR) between the confirmed infection or the last vaccination dose and the day when samples were taken ("sampling interval") was 3.67 (2.03, 5.50) months in the RA group. Anti-Spike (anti-S) specific antibodies were detecte

SUBMITTER: Nemeth D 

PROVIDER: S-EPMC9596981 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature