The prognostic significance of PD-L1 expression in patients with glioblastoma: A meta-analysis.

ABSTRACT:

Background

Glioblastoma (GBM) is a malignant brain tumor associated with high morbidity and mortality rates with a poor prognosis. In recent years, studies on prognostic markers such as programmed death ligand 1 (PD-L1) have increased; however, their conclusions remain controversial. Here, relevant literature was reviewed and a meta-analysis was performed to clarify the correlation between PD-L1 expression and overall survival (OS) in GBM.

Methods

The non-foundational literature on PD-L1 expression associated with OS in GBM up to February 2022 was searched in the PubMed, Metstr, Cochrane, and Web of Science databases. Literature was rigorously screened according to inclusion and exclusion criteria, the total hazard ratio (HR), and corresponding 95% confidence intervals (CIs)

SUBMITTER: Guo X 

PROVIDER: S-EPMC9596987 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature