Ontology highlight
ABSTRACT:
SUBMITTER: An R
PROVIDER: S-EPMC9597210 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
An Ran R Wang Junyan J Chen Xuan X Xu Ruifeng R Hu Jisheng J Liu Zhongying Z Wei Chanjuan C Zhang Chenxi C Yuan Baiyin B
Experimental biology and medicine (Maywood, N.J.) 20220721 18
As a major co-factor of F-actin depolymerization, WD-repeat domain 1 (WDR1) affects the cellular microenvironment by cytoskeleton remodeling, thereby influencing cell molecular behavior. Our previous study showed that WDR1 activates YAP (Yes-associated protein) signaling in non-small-cell lung cancer (NSCLC) cells, but the mechanism remains unclear. We discovered that knockdown WDR1 in NSCLC cells decreased the expression of YAP and the nucleus-to-cytoplasm ratio. Disruption of cortical stress b ...[more]