Non-reference genome transposable elements (TEs) have a significant impact on the progression of the Parkinson's disease.

ABSTRACT: The pathophysiology of Parkinson's disease (PD) is a complex process of the interaction between genetic and environmental factors. Studies on the genetic component of PD have predominantly focused on single nucleotide polymorphisms (SNPs) using a cross-sectional case-control design in large genome-wide association studies. This approach while giving insight into a significant portion of the genetics of PD does not fully account for all the genetic components resulting in missing heritability. In this study, we approached this problem by focusing on the non-reference genome transposable elements (TEs) and their impact on the progression of PD using a longitudinal study design within the Parkinson's progression markers initiative (PPMI) cohort. We analyzed 2886 Alu repeats, 360 LINE1 and 128

SUBMITTER: Koks S 

PROVIDER: S-EPMC9597212 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature