Hemodynamic effect of pimobendan following intramuscular and intravenous administration in healthy dogs: A pilot study.

ABSTRACT:

Background

Pimobendan is widely used for the treatment of dogs with heart failure via the oral route. A new injectable form of pimobendan is now available and its potential usefulness via intravenous route has been recently demonstrated in dogs. However, the cardiovascular effects of intramuscular (IM) administration of injectable pimobendan have not been investigated yet.

Hypothesis

IM administration of pimobendan may have the same hemodynamic effect as the IV route.

Methods

Six healthy Beagle dogs underwent a placebo-controlled double-blind crossover study. The early cardiovascular effects after a single dose of IM and IV injections of pimobendan (0.2 ml/kg; Pimo IM and Pimo IV, respectively) were compared to the same volume of IM placebo (Saline IM) i

SUBMITTER: Enokizono M 

PROVIDER: S-EPMC9597246 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature