Orai1-mediated store-operated Ca²⁺ entry promotes cervical cancer progression through IL-6 signaling.

ABSTRACT: Cervical cancer is a major cause of cancer-associated mortality among women in developing countries. Orai1-mediated store-operated Ca²⁺ entry (SOCE) is the primary mechanism underlying most of the non-excitable calcium influx into cells. There is at present limited evidence showing that Orai1 can function as an oncogene or a tumor suppressor depending on the cancer type. Furthermore, the exact biological functions of Orai1 in cervical cancer and the underlying mechanisms are still poorly understood. In this study, we found that Orai1 was upregulated in cervical cancer tissues, and promoted the growth of human cervical cancer cells both in vitro and in vivo. Gene silencing of Orai1 in cervical cancer cells significantly decreased interleukin (IL)-6 secretion. Intere

SUBMITTER: Pan Y 

PROVIDER: S-EPMC9597359 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature