Extracellular vesicle miRNAs in breast milk of obese mothers.

ABSTRACT:

Background

Breast milk has abundant extracellular vesicles (EVs) containing various biological molecules (cargo), including miRNAs. EVs are not degraded in the gastrointestinal system and circulation; thus, breast milk EVs (bEVs) are expected to interact with other organs in breastfed infants and modify the gene expression of recipient cells using miRNAs. Maternal pre-pregnancy BMI is a critical factor influencing the composition of breast milk. Thus, in mothers with obesity, miRNAs in bEVs can be altered, which might be associated with adverse health outcomes in infants. In this study, we examined 798 miRNAs to determine which miRNAs are altered in the bEVs of mothers with obesity and their potential impact on breastfed infants.

Methods

We recruited healthy nursing mothers

SUBMITTER: Cho YE 

PROVIDER: S-EPMC9597365 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature