Menstrual Cycle Regularity and Length Across the Reproductive Lifespan and Risk of Cardiovascular Disease.

ABSTRACT:

Importance

Menstrual cycle characteristics may be associated with an increased risk of cardiovascular disease (CVD). However, existing studies are limited, and few have explored the mediating role of established CVD risk factors.

Objective

To explore the associations of menstrual cycle characteristics across the reproductive lifespan with the risk of CVD and to what extent these associations were mediated by hypercholesterolemia, chronic hypertension, and type 2 diabetes.

Design, setting, and participants

This cohort study prospectively followed Nurses' Health Study II participants between 1993 and 2017 who reported menstrual cycle regularity and length for ages 14 to 17 years and 18 to 22 years at enrollment in 1989 and updated current cycle characteristics in 1993 (

SUBMITTER: Wang YX 

PROVIDER: S-EPMC9597395 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature