Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease.

ABSTRACT:

Importance

Kidney function is usually estimated from serum creatinine level, whereas an alternative glomerular filtration marker (cystatin C level) associates more closely with future risk of cardiovascular disease (CVD) and mortality.

Objectives

To evaluate whether testing concordance between estimated glomerular filtration rates based on cystatin C (eGFRcys) and creatinine (eGFRcr) levels would improve risk stratification for future outcomes and whether estimations differ by age.

Design, setting, and participants

A prospective population-based cohort study (UK Biobank), with participants recruited between 2006-2010 with median follow-up of 11.5 (IQR, 10.8-12.2) years; data were collected until August 31, 2020. Participants had eGFRcr greater than or equal to 45 mL/m

SUBMITTER: Lees JS 

PROVIDER: S-EPMC9597396 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature