Low serum level of 25-OH vitamin D relates to Th17 and treg changes in colorectal cancer patients.

ABSTRACT:

Background

Serum 25-hydroxyvitamin D [25(OH)D] level alters in colorectal cancer (CRC) development. Regulatory T (Treg) cells and T- helper type 17 (Th17) cells are involved in immune response. Th17-mediated proinflammatory responses contribute to tumorigenesis, and Treg plays different roles in different periods of CRC. Vitamin D deficiency is associated with significant variations in peripheral immune cells. This study investigated the relationship between Th17 and Treg cells and 25(OH)D level in CRC.

Methods

Ninety-five CRC patients were included, as well as 80 healthy controls during the same period at the Affiliated Hospital of Jiangnan University. 25(OH)D level was analyzed through electrochemiluminescence (ECLIA). Th17 and Treg levels were evaluated through flow cytom

SUBMITTER: Chen B 

PROVIDER: S-EPMC9597490 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature