Associations of circadian rest/activity rhythms with cognition in middle-aged and older adults: Demographic and genetic interactions.

ABSTRACT:

Objectives

Wrist actigraphs (accelerometers) can record motor activity over multiple days and nights. The resulting data can be used to quantify 24-h activity profiles, known as circadian rest-activity rhythms (CRARs). Actigraphic CRARs have been tied to cognitive performance and decline in older adults; however, little is known about links between CRARs and performance or change in specific cognitive domains, or how individual differences may influence these associations. We investigated associations of actigraphic CRARs with cognitive performance and change in middle-aged and older adults, and explored whether age, sex/gender, race, and apolipoprotein E (APOE) e4 carrier status moderated these associations.

Materials and methods

Participants (N = 422; 47% male) were

SUBMITTER: Rabinowitz JA 

PROVIDER: S-EPMC9597505 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature