Chromosome organization affects genome evolution in Sulfolobus archaea.

ABSTRACT: In all organisms, the DNA sequence and the structural organization of chromosomes affect gene expression. The extremely thermophilic crenarchaeon Sulfolobus has one circular chromosome with three origins of replication. We previously revealed that this chromosome has defined A and B compartments that have high and low gene expression, respectively. As well as higher levels of gene expression, the A compartment contains the origins of replication. To evaluate the impact of three-dimensional organization on genome evolution, we characterized the effect of replication origins and compartmentalization on primary sequence evolution in eleven Sulfolobus species. Using single-nucleotide polymorphism analyses, we found that distance from an origin of replication was associated with increased mutat

SUBMITTER: Badel C 

PROVIDER: S-EPMC9597579 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature