Identifying a Hidden Conglomerate Chiral Pool in the CSD.

ABSTRACT: Conglomerate crystallization is the spontaneous generation of individually enantioenriched crystals from a nonenantioenriched material. This behavior is responsible for spontaneous resolution and the discovery of molecular chirality by Pasteur. The phenomenon of conglomerate crystallization of chiral organic molecules has been left largely undocumented, with no actively curated list available in the literature. While other crystallographic behaviors can be interrogated by automated searching, conglomerate crystallizations are not identified within the Cambridge Structural Database (CSD) and are therefore not accessible by conventional automated searching. By conducting a manual search of the CSD and literature, a list of over 1800 chiral species capable of conglomerate crystallization was

SUBMITTER: Walsh MP 

PROVIDER: S-EPMC9597607 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature