Novel synthesis of fibronectin derived photoluminescent carbon dots for bioimaging applications.

ABSTRACT: Fibronectin (FN) derived from human plasma has been used for the first time as the carbon precursor in the top-down, microwave-assisted hydrothermal synthesis of nitrogen doped carbon dots (CDs). FN is a large glycoprotein primarily known for its roles in cell adhesion and cell growth. Due to these properties FN can be over expressed in the extracellular matrix (ECM) of some cancers allowing FN to be used as an indicator for the detection of cancerous cells over non-cancerous cells. These FN derived CDs display violet photoluminescence with UV excitation and appear to possess similar functional groups on their surface to their carbon precursor (-COOH and -NH₂). This is believed to be due to the self-passivation of the CDs' nitrogen-containing surface functional groups during the

SUBMITTER: Strickland S 

PROVIDER: S-EPMC9597609 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature