The Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited.

ABSTRACT:

Background

Two studies that examined the interaction between HLA-DRB1 and smoking in Parkinson's disease (PD) yielded findings in opposite directions.

Objective

To perform a large-scale independent replication of the HLA-DRB1 × smoking interaction.

Methods

We genotyped 182 single nucleotide polymorphism (SNPs) associated with smoking initiation in 12 424 cases and 9480 controls to perform a Mendelian randomization (MR) analysis in strata defined by HLA-DRB1.

Results

At the amino acid level, a valine at position 11 (V11) in HLA-DRB1 displayed the strongest association with PD. MR showed an inverse association between genetically predicted smoking initiation and PD only in absence of V11 (odds ratio, 0.74, 95% confidence interval, 0.59-0.93, P_Interaction

SUBMITTER: Domenighetti C 

PROVIDER: S-EPMC9597672 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature