Characterisation of TRIM46 autoantibody-associated paraneoplastic neurological syndrome.

ABSTRACT:

Objectives

To report the expanded neurological presentations and oncological associations of tripartite motif-containing protein 46 (TRIM46)-IgG seropositive patients.

Methods

Archived sera/cerebrospinal fluid (CSF) were evaluated by tissue-based immunofluorescence assay to identify patients with identical axon initial segment (AIS)-specific staining pattern. Phage immunoprecipitation sequencing (PhIP-Seq) was used to identify the putative autoantigen.

Results

IgG in serum (17) and/or CSF (16) from 25 patients yielded unique AIS-specific staining on murine central nervous system (CNS) tissue. An autoantibody specific for TRIM46 was identified by PhIP-Seq, and autoantigen specificity was confirmed by transfected COS7 cell-based assay. Clinical information was available

SUBMITTER: Valencia-Sanchez C 

PROVIDER: S-EPMC9597704 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature