Alkali halides as nucleophilic reagent sources for N-directed palladium-catalysed ortho-C-H halogenation of s-tetrazines and other heteroaromatics.

ABSTRACT: A general palladium-catalysed selective C-H halogenation reaction is reported, which was successfully achieved for a large variety of functionalized aromatic rings incorporating diverse N-directing groups. By using simple alkali halides of MX type as the nucleophilic reagent source (M = Li, Na, K, Cs and X = I, Br and Cl), and phenyliodanediacetate oxidant, clean C-H-iodination, bromination and chlorination reactions were performed. This general protocol of selective ortho-monohalogenation, which complements but contrasts with the classical methods using electrophilic reagents, is achievable in a short time (30 min) with microwave irradiation assistance. The reaction was extended to substrates bearing N-directing pyridine, pyrimidine, pyrazole, oxazoline, naphtho[1,2-d]thiazo

SUBMITTER: Daher A 

PROVIDER: S-EPMC9597855 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature