Aberrant brain functional networks in type 2 diabetes mellitus: A graph theoretical and support-vector machine approach.

ABSTRACT:

Objective

Type 2 diabetes mellitus (T2DM) is a high risk of cognitive decline and dementia, but the underlying mechanisms are not yet clearly understood. This study aimed to explore the functional connectivity (FC) and topological properties among whole brain networks and correlations with impaired cognition and distinguish T2DM from healthy controls (HC) to identify potential biomarkers for cognition abnormalities.

Methods

A total of 80 T2DM and 55 well-matched HC were recruited in this study. Subjects' clinical data, neuropsychological tests and resting-state functional magnetic resonance imaging data were acquired. Whole-brain network FC were mapped, the topological characteristics were analyzed using a graph-theoretic approach, the FC and topological characteristics of t

SUBMITTER: Lin L 

PROVIDER: S-EPMC9597867 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature