Examination of Immunogenic Properties of Recombinant Antigens Based on p22 Protein from African Swine Fever Virus.

ABSTRACT:

Introduction

The single member of the Asfarviridae family is African swine fever virus (ASFV). This double-stranded DNA virus infects wild and farmed swine and loses the pig industry large sums of money. An inner envelope, capsid, and outer envelope are parts of the ASFV particle containing structural proteins playing different roles in the process of infection or host immune defence evasion. When expressed by the baculovirus system, the p22 protein from the inner envelope was found to induce partial protection against a virulent virus strain. This study aimed to express a part of this protein in a different system and evaluate its immunogenicity.

Material and methods

We designed two proteins, the extracellular (C terminal) part of the p22 protein (p22Ct) and its fusion with

SUBMITTER: Diaz C 

PROVIDER: S-EPMC9597933 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature