A potential pathogenic hypoxia-related gene HK2 in necrotizing enterocolitis (NEC) of newborns.

ABSTRACT:

Background

Necrotizing enterocolitis (NEC) is a disastrous gastrointestinal disease of newborns, and the mortality rate of infants with NEC is approximately 20%-30%. The exploration of pathogenic targets of NEC will be conducive to timely diagnosis of NEC.

Methods

The whole transcriptome RNA sequencing was performed on NEC samples to reveal the expression of lncRNAs, circRNAs, miRNAs and mRNAs. Using differential expression analysis, cross analysis, target prediction, enrichment analysis, the pathogenic ceRNA network and target was found.

Results

Preliminarily, 281 DEmRNAs, 21 DEmiRNAs, 253 DElncRNAs and 207 DEcircRNAs were identified in NEC samples compared with controls. After target prediction and cross analyses, a key ceRNA regulatory network was built including 2

SUBMITTER: Han Y 

PROVIDER: S-EPMC9597967 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature