Structural and developmental dynamics of Matrix associated regions in Drosophila melanogaster genome.

ABSTRACT:

Background

Eukaryotic genome is compartmentalized into structural and functional domains. One of the concepts of higher order organization of chromatin posits that the DNA is organized in constrained loops that behave as independent functional domains. Nuclear Matrix (NuMat), a ribo-proteinaceous nucleoskeleton, provides the structural basis for this organization. DNA sequences located at base of the loops are known as the Matrix Attachment Regions (MARs). NuMat relates to multiple nuclear processes and is partly cell type specific in composition. It is a biochemically defined structure and several protocols have been used to isolate the NuMat where some of the steps have been critically evaluated. These sequences play an important role in genomic organization it is imperative to k

SUBMITTER: Sureka R 

PROVIDER: S-EPMC9597980 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature