Neutrophil degranulation and severely impaired extracellular trap formation at the basis of susceptibility to infections of hemodialysis patients.

ABSTRACT:

Background

Chronic kidney disease patients are at increased risk of mortality with cardiovascular diseases and infections as the two leading causes of death for end-stage kidney disease treated with hemodialysis (HD). Mortality from bacterial infections in HD patients is estimated to be 100-1000 times higher than in the healthy population.

Methods

We comprehensively characterized highly pure circulating neutrophils from HD and healthy donors.

Results

Protein levels and transcriptome of HD patients' neutrophils indicated massive neutrophil degranulation with a dramatic reduction in reactive oxygen species (ROS) production during an oxidative burst and defective oxidative cellular signaling. Moreover, HD neutrophils exhibit severely impaired ability to generate extracel

SUBMITTER: Talal S 

PROVIDER: S-EPMC9597999 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature