Inflammation and cell-to-cell communication, two related aspects in frailty.

ABSTRACT:

Background

Frailty is a complex, multi-dimensional age-related syndrome that increases the susceptibility to adverse health outcomes and poor quality of life. A growing consensus supports the contribution of chronic inflammation and immune system alterations to frailty, however a clear role of such alterations remains to be elucidated. Furthermore, pro- and anti-inflammatory cytokines together with other signaling molecules might spread from activated cells to the adjacent ones through extracellular vesicles (EVs), which have also a role in cellular aging. The aim of the present research was to investigate if EVs play a role in the immune function in frailty.  RESULTS: In 219 older adults aged 76-78 years, selected from the InveCe.Ab study (Abbiategrasso, Italy), we investigated in

SUBMITTER: Pansarasa O 

PROVIDER: S-EPMC9598012 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature