Effects of Copper Exposure on Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress, Autophagy and Immune Response in Different Tissues of Chinese Mitten Crab (Eriocheir sinensis).

ABSTRACT: High concentrations of copper (Cu²⁺) pose a great threat to aquatic animals. However, the mechanisms underlying the response of crustaceans to Cu²⁺ exposure have not been well studied. Therefore, we investigated the alterations of physiological and molecular parameters in Chinese mitten crab (Eriocheir sinensis) after Cu²⁺ exposure. The crabs were exposed to 0 (control), 0.04, 0.18, and 0.70 mg/L of Cu²⁺ for 5 days, and the hemolymph, hepatopancreas, gills, and muscle were sampled. The results showed that Cu²⁺ exposure decreased the antioxidative capacity and promoted lipid peroxidation in different tissues. Apoptosis was induced by Cu²⁺ exposure, and this activation was associated with the mitochondrial and ERK pathw

SUBMITTER: Feng W 

PROVIDER: S-EPMC9598082 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature