Neuroprotective Effect of Abelmoschus manihot Flower Extracts against the H₂O₂-Induced Cytotoxicity, Oxidative Stress and Inflammation in PC12 Cells.

ABSTRACT: The progression of neurodegenerative diseases is associated with oxidative stress and inflammatory responses. Abelmoschus manihot L. flower (AMf) has been shown to possess excellent antioxidant and anti-inflammatory activities. This study investigated the protective effect of ethanolic extract (AME), water extract (AMW) and supercritical extract (AMS) of AMf on PC12 neuronal cells under hydrogen peroxide (H2O2) stimulation. This study also explored the molecular mechanism underlying the protective effect of AME, which was the best among the three extracts. The experimental results showed that even at a concentration of 500 μg/mL, neither AME nor AMW showed toxic effects on PC12 cells, while AMS caused about 10% cell death. AME has the most protective effect on apoptosis of PC12 cells stimu

SUBMITTER: Wang SW 

PROVIDER: S-EPMC9598102 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature