Cytokine Profile at Diagnosis Affecting Trough Concentration of Infliximab in Pediatric Crohn's Disease.

ABSTRACT:

Background

This study aims to measure the concentration of cytokines produced during the inflammation process to investigate if there are any differences in response to treatment of pediatric Crohn's disease and to determine if the initial tumor necrosis factor-alpha (TNF-α) level affected the trough concentration of infliximab (IFX).

Methods

This study included 30 pediatric patients with moderate-to-severe Crohn's disease. At the time of diagnosis, blood samples were collected for the measurement of cytokines (IL-6, TNF-α, IL-17A, and IL-10). Blood samples were extracted from patients who had begun IFX treatment to measure the IFX trough concentration immediately before the fourth dose administration.

Results

All cytokines (TNF-α, IL-6, IL-10, and IL-17A) were signif

SUBMITTER: Kwon Y 

PROVIDER: S-EPMC9598182 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature