Conditioned Medium from H₂O₂-Preconditioned Human Adipose-Derived Stem Cells Ameliorates UVB-Induced Damage to Human Dermal Fibroblasts.

ABSTRACT: Human skin exposure to ultraviolet B (UVB) radiation can result in acute photodamage through oxidative modifications of cellular components and biomolecules involved in the metabolism of dermal cells. Recently, the therapeutic potential of human adipose-derived stem cells (hASCs) has been investigated as a novel strategy for photoprotection due to their pro-angiogenic properties, protective activity against oxidative stress and paracrine effect on dermal cells. To enhance these therapeutic properties, hASCs can be preconditioned by exposing them to sublethal cellular stressors. In this study, we first analyzed response capacity against UVB-induced oxidative stress in H₂O₂-preconditioned hASCs (called HC016 cells); and second, we evaluated the photoprotective effect of

SUBMITTER: Buron M 

PROVIDER: S-EPMC9598226 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature