Antioral Cancer Effects by the Nitrated [6,6,6]Tricycles Compound (SK1) In Vitro.

ABSTRACT: A novel nitrated [6,6,6]tricycles-derived compound containing nitro, methoxy, and ispropyloxy groups, namely SK1, was developed in our previous report. However, the anticancer effects of SK1 were not assessed. Moreover, SK1 contains two nitro groups (NO₂) and one nitrogen-oxygen (N-O) bond exhibiting the potential for oxidative stress generation, but this was not examined. The present study aimed to evaluate the antiproliferation effects and oxidative stress and its associated responses between oral cancer and normal cells. Based on the MTS assay, SK1 demonstrated more antiproliferation ability in oral cancer cells than normal cells, reversed by N-acetylcysteine. This suggests that SK1 causes antiproliferation effects preferentially in an oxidative stress-dependent manner

SUBMITTER: Chen YN 

PROVIDER: S-EPMC9598307 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature