Reelin Protects against Colon Pathology via p53 and May Be a Biomarker for Colon Cancer Progression.

ABSTRACT: Previous observations made in human and mouse colons suggest that reelin protects the colon from pathology. In this study, we evaluated reelin expression during the transition from either colitis or precancerous lesions to colon cancer and tried to elucidate reelin regulation under these transition processes. Samples of healthy and pathological colons from humans and mice treated with either azoxymethane/dextran sulfate sodium (DSS) or azoxymethane alone were used. The relative abundances of reelin, DNMT-1 and ApoER2 mRNAs were determined by PCR in the colon samples cited above and in the tissue adjacent to mouse colon polyps and adenocarcinomas. In both, humans and mice, reelin mRNA abundance increased significantly in ulcerative colitis and slightly in polyps and decreased in adenomas an

SUBMITTER: Serrano-Morales JM 

PROVIDER: S-EPMC9598338 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature