Luteolin-Induced Activation of Mitochondrial BK_Ca Channels: Undisclosed Mechanism of Cytoprotection.

ABSTRACT: Luteolin (LUT) is a well-known flavonoid that exhibits a number of beneficial properties. Among these, it shows cardioprotective effects, as confirmed by numerous studies. However, its effect on mitochondrial potassium channels, the activation of which is related to cytoprotection, as well as on heart ischemia/reperfusion (I/R) damage prevention, has not yet been investigated. The large conductance calcium-regulated potassium channel (mitoBK_Ca) has been identified in both the mitochondria of the vascular endothelial cells, which plays a significant role in the functioning of the cardiovascular system under oxidative stress-related conditions, and in the mitochondria of cardiomyocytes, where it is deeply involved in cardiac protection against I/R injury. Therefore, the aim of thi

SUBMITTER: Kampa RP 

PROVIDER: S-EPMC9598376 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature